PhD Position in Aquatic Toxicology of PFAS

A PhD position to assess the effects of PFAS on aquatic organisms is available in the Junior Research Group Gölz, BioQuant, Heidelberg University.

Description:

This interdisciplinary research project explores the effects and mechanisms of PFAS at different biological levels, with a special focus on cardiovascular toxicity and additional interest in endocrine-related mechanisms. By working at the intersection of human and environmental toxicology, you will have the opportunity to advance Adverse Outcome Pathways (AOPs) and support the development of New Approach Methods (NAMs), thereby contributing to a more sustainable and responsible management of environmental chemicals.

Research Areas and Methodological Focus:

1. PFAS Toxicity and Underlying Mechanisms in Zebrafish Embryos

  • Analysis of PFAS effects across different biological levels using molecular biology techniquessuch as gene expression analysis and transcriptomics, as well as histological methods
  • Physiological investigations of cardiovascular effects, including heart rate measurements and live imaging
  • Behavioral analyses to assess neurotoxicity and developmental impairment, including swimming behavior and light response assays

2. Development of Ecotoxicological Endpoints for PFAS Effects

  • Application of current OECD fish test guidelines to evaluate PFAS effects in aquatic model systems, particularly OECD TG 236 (Zebrafish FET Test)
  • Investigation of endpoints for the detection of cardiotoxicity, neurotoxicity and endocrine disruption induced by PFAS

3. AOP Development and Interdisciplinary Research

  • Investigation of causal relationships across different biological levels
  • Support for the further development of Adverse Outcome Pathways (AOPs) in toxicology

Your Profile:

We are looking for highly motivated graduates with a Master’s degree in Life Sciences, Environmental Sciences, Toxicology, Pharmacy, or a related field, who are enthusiastic about independent scientific work and able to contribute effectively to a collaborative team environment

Applicants should have experience in one or more of the following areas:

  • Fish husbandry and practical work with zebrafish is required
  • OECD test protocols, especially OECD TG 236 (FET test) and other ecotoxicological fish assays
  • Molecular biology and biochemical methods, including gene expression analysis andtranscriptomics
  • Histological and microscopic techniques, as well as immunohistochemistry
  • Analysis of endocrine organs as well as neuronal and cardiovascular structures
  • Behavioral analysis, including swimming behavior and light response

In addition, you should have:

  • An independent, responsible and committed working style
  • Strong teamwork skills
  • Very good written and spoken English skills

We Offer:

  • Modern laboratory infrastructure and innovative technologies
  • Active participation in scientific meetings and conferences
  • Access to targeted training opportunities in ecotoxicology, 3R, tissue engineering, biomedicine,and cardiovascular research
  • An excellent working atmosphere in a dynamic, young team within the newly established Junior Research Group Gölz

Application:

Please send your application documents, including a motivation letter, CV and relevant certificates, by 7th April, 2026 to: lisa.goelz@bioquant.uni-heidelberg.de

For more information, kindly contact:

Dr. Lisa Marie Gölz BioQuant,

Heidelberg University

Im Neuenheimer Feld 267

69120 Heidelberg